Facile synthesis of azaarene-2-substituted chromanone derivatives via tandem sp³C–H functionalization/decarboxylation of azaarenes with 4-oxo-4H-chromene-3-carboxylic acid

Abstract

A facile catalyst-free tandem sp³C–H functionalization/decarboxylation of 4-oxo-4<italic>H</italic>-chromene-3-carboxylic acid with 2-alkylazaarenes was developed, which can construct the biologically significant azaarene 2-substituted chromanones in a single step.