Concepedia

Sodium Channel Mutations and Susceptibility to Heart Failure and Atrial Fibrillation

JAMA · 2005 · 550 citations · 33 references

Open access

Abstract

Heritable SCN5A defects are associated with susceptibility to early-onset DCM and atrial fibrillation. Similar or even identical mutations may lead to heart failure, arrhythmia, or both.

References

33

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

Qiuyun Chen, Glenn E. Kirsch, Danmei Zhang et al. · Nature · 1998 · 1.8K citations

Cardiac Muscle, Cardiomyopathy, Heart Failure +6

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

Q. Wang, Mark Curran, Igor Splawski et al. · Nature Genetics · 1996 · 1.8K citations

Cardiac Muscle, Channelopathies, Kvlqt1 Mutations +9

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

Qing Wang, Jiaxiang Shen, Igor Splawski et al. · Cell · 1995 · 1.7K citations · Full text

Long Qt Syndrome, Cardiomyopathy, Genetic Disorder +6

Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease

Diane Fatkin, Calum A. MacRae, Takeshi Sasaki et al. · New England Journal of Medicine · 1999 · 1.3K citations · Full text

Spectrum of Mutations in Long-QT Syndrome Genes

Igor Splawski, Jiaxiang Shen, Katherine W. Timothy et al. · Circulation · 2000 · 1.2K citations · Full text