Cell fate regulation by gelsolin in human gynecologic cancers

Abstract

Significance We tested the hypothesis that gelsolin (GSN) plays an important role in gynecological chemoresistance through the following: We provided strong evidence in support of GSN as an important etiologic factor in chemoresistance in vitro. We also determined the mechanism by which GSN exerts its prosurvival action. Our findings also suggest that the application of C-terminal GSN may represent a new therapeutic strategy for chemoresistant gynecologic cancer. We have also validated our in vitro findings with a clinical investigation that determines the relationship between GSN expression and cis -Diammine dichloroplatinium (II) sensitivity in human ovarian tumor. These findings agree with the notion that GSN plays a key role in the regulation of gynecological cell fate as reflected in chemoresistance.