Downregulation of HMGB1 protects against the development of acute lung injury after severe acute pancreatitis

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Paola Scaffidi, Tom Misteli, Marco E. Bianchi · Nature · 2002 · 4.1K citations

Inflammation, Chromatin, Cytokine +10

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

Haichao Wang, Ona Bloom, Minghuang Zhang et al. · Science · 1999 · 3.4K citations

Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein

Jong Sung Park, Daiva Svetkauskaite, Qianbin He et al. · Journal of Biological Chemistry · 2004 · 1.5K citations · Full text

High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes

Haichao Wang, Karin Palmblad, Ann-Charlotte Aveberger et al. · The Journal of Experimental Medicine · 2000 · 1.4K citations · Full text

Reversing established sepsis with antagonists of endogenous high-mobility group box 1

Huan Yang, Mahendar Ochani, Jianhua Li et al. · Proceedings of the National Academy of Sciences · 2003 · 1.1K citations · Full text

Inflammation, Specific Inhibition, Cytokine +15