Liver Adenine Nucleotides: Fructose-Induced Depletion and Its Effect on Protein Synthesis

Abstract

Intravenous administration of D-fructose to rats rapidly depletes liver adenosine triphosphate and inorganic phosphate; marked elevations of uric acid and allantoin in plasma follow. Concomitantly the incorporation of DL-leucine-1-(14)C into liver protein is almost completely inhibited.