Chemistry - A European Journal · 2010 · 87 citations · 14 references
PharmacyMedicinal ChemistryPharmacologyCombinatorial ChemistryDrug DiscoverySynthetic Medicinal ChemistryAnthelmintic PharmacologyCombinatorial SynthesisAnthelmintic Drug DevelopmentAntiparasitic Drug DiscoveryEmerging Antiparasitic AgentsMulticomponent Reaction ChemistryPraziquantel AnthelminticsSchistosomiasis TreatmentSchistosomicidal AgentsSynthetic Antiparasitic Compounds
Shorter than ever: A convergent, efficient, and scalable access based on a key Ugi four-component reaction (4CR) followed by a Pictet–Spengler reaction comprises the shortest known synthesis to the schistosomiasis drug praziquantel (see scheme).
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The use of the Ugi four-component condensation
Stefano Marcaccini, Tomás Torroba · Nature Protocols · 2007 · 206 citations