Application of Fourier Transform Spectroscopy to Magnetic Resonance

TLDR

The study explores applying a novel Fourier transform technique to magnetic resonance spectroscopy. The method uses short RF pulse sequences followed by Fourier transformation of the system response, with sensitivity boosted by the square root of the line‑width to total‑width ratio. The technique yields spectra in a fraction of the time and up to tenfold higher sensitivity, achieving a 100‑fold reduction in acquisition time compared to conventional methods, especially benefiting complex high‑resolution spectra.

Abstract

The application of a new Fourier transform technique to magnetic resonance spectroscopy is explored. The method consists of applying a sequence of short rf pulses to the sample to be investigated and Fourier-transforming the response of the system. The main advantages of this technique compared with the usual spectral sweep method are the much shorter time required to record a spectrum and the higher inherent sensitivity. It is shown theoretically and experimentally that it is possible to enhance the sensitivity of high resolution proton magnetic resonance spectroscopy in a restricted time up to a factor of ten or more. The time necessary to achieve the same sensitivity is a factor of 100 shorter than with conventional methods. The enhancement of the sensitivity is essentially given by the square root of the ratio of line width to total width of the spectrum. The method is of particular advantage for complicated high resolution spectra with much fine structure.