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Is engineering O2-tolerant hydrogenases just a matter of reproducing the active sites of the naturally occurring O2-resistant enzymes?

EngineeringActive SitesMolecular BiologyRedox BiologyBioenergeticsBiochemical EngineeringMetabolic EngineeringStructure-function Enzyme KineticsO2-resistant EnzymesBiochemistryBiocatalysisEngineering O2-tolerant HydrogenasesBiomolecular EngineeringCellular EnzymologyNatural SciencesEnzyme CatalysisBiotechnologyGenetic EngineeringSynthetic BiologyEnzyme Specificity