Coexistence of HLA-B*08 and HLA-B*18 in Four Siblings with Lichen sclerosus

Abstract

BACKGROUND: Lichen sclerosus (LS), is characterized by localized patches of atrophy and whitening of the skin. The cause of LS remains unknown, but genetic, hormonal, immunologic factors and autoimmune mechanisms have been incriminated. There are conflicting data regarding the association between LS and human leukocyte antigens (HLA). METHODS: We have analyzed the HLA alleles of a family, in which 4 of 5 children have lichen sclerosus. RESULTS: HLA-B*08 and HLA-B*18 alleles were detected in children with LS, but not in a healthy sister. None of the patients had autoimmune disease. CONCLUSION: In our opinion, coexistence of these two alleles may play a role in the development of LS.