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Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: a role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapy

Robbert van der Most, Andrew Currie, Sathish Mahendran, Amy Prosser, Anna Darabi, Bruce Robinson, Anna K. Nowak, Richard Lake

Cancer Immunology Immunotherapy · 2008 · 125 citations · 37 references

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37

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

Johannes Gerdes, Hilmar Lemke, H. Baisch et al. · The Journal of Immunology · 1984 · 4.2K citations

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Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

François Ghiringhelli, Cédric Menard, Pierre E. Puig et al. · Cancer Immunology Immunotherapy · 2006 · 1.2K citations · Full text

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Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell–suppressive activity

Kiavash Movahedi, Martin Guilliams, Jan Van den Bossche et al. · Blood · 2008 · 1.2K citations

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Gemcitabine Selectively Eliminates Splenic Gr-1+/CD11b+ Myeloid Suppressor Cells in Tumor-Bearing Animals and Enhances Antitumor Immune Activity

Eiji Suzuki, Veena Kapoor, Arminder S. Jassar et al. · Clinical Cancer Research · 2005 · 1.1K citations

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Inhibition of CD4+25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

M. E. Christine Lutsiak, Roshanak Tolouei Semnani, Roberto De Pascalis et al. · Blood · 2005 · 896 citations · Full text

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