Polymerase chain reaction-single strand conformation polymorphism analysis of the p53 gene in paraffin-embedded surgical material from human renal cell carcinomas

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

Masato Orita, Hiroyuki Iwahana, Hiroshi Kanazawa et al. · Proceedings of the National Academy of Sciences · 1989 · 3.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +14

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

Masato Orita, Youichi Suzuki, Takao Sekiya et al. · Genomics · 1989 · 3.5K citations

Life Sciences, Genetics, Molecular Genetics +16

Mutations in the p53 gene occur in diverse human tumour types

Janice Nigro, Suzanne J. Baker, Antonette C. Preisinger et al. · Nature · 1989 · 2.8K citations · Full text

Life Sciences, Genetics, Molecular Genetics +12

Purification of DNA from formaldehyde fixed and paraffin embedded human tissue

Susan Goelz, Stanley R. Hamilton, Bert Vogelstein · Biochemical and Biophysical Research Communications · 1985 · 811 citations

Medicine, Molecular Biology, Pathology +9

Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas.

Y. Murakami, Koutarou Hayashi, S Hirohashi et al. · PubMed · 1991 · 378 citations

Medicine, Genetics, Oncology +17