Influence of Smoking, Hypertension, and Sex on the Phenotypic Expression of Familial Intracranial Aneurysms in Siblings

Abstract

Together these data suggest that hypertension, smoking, and female sex increase the likelihood that a member of a family with an expressed FIA will have an aneurysm. These observations may prove helpful in guiding the use of screening studies and encouraging education about the potential risks of continued tobacco use and untreated hypertension in this patient cohort.