Publication | Open Access
Biomimetic Hydroxylation of Nonactivated CH<sub>2</sub> Groups with Copper Complexes and Molecular Oxygen
117
Citations
43
References
2003
Year
Steroidal LigandsInorganic ChemistryChemical EngineeringEngineeringBiochemistryBiomimetic HydroxylationNatural SciencesCoordination Complex17β,12β-Amino AlcoholMolecular OxygenBioorganometallic ChemistryOrganic ChemistryCopper ComplexesCatalysisRedox ChemistryChemistryOrganometallic Catalysis
Copper(I) complexes with steroidal ligands (see formula) undergo regio- and stereoselective γ-hydroxylation in the 12β-position of the steroid in the presence of molecular oxygen. After reduction a 17β,12β-amino alcohol is obtained. Under hydrolytic conditions a 12β-hydroxy-17-ketone can be isolated.
| Year | Citations | |
|---|---|---|
Page 1
Page 1