Selective inhibition of platelet lipoxygenase by esculetin

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Aspirin-like Drugs, Prostaglandin Synthesis, Biochemistry +8

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

A. W. Ford‐Hutchinson, M.A. Bray, Mira Doig et al. · Nature · 1980 · 2.1K citations

Inflammation, Cytokine, Granulocyte +10

Arachidonate lipoxygenase in blood platelets

D.H. Nugteren · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1975 · 618 citations

Thrombopoiesis, Thrombosis, Biochemistry +8

A new approach to anti-inflammatory drugs

G.A. Higgs, Roderick J. Flower, John R. Vane · Biochemical Pharmacology · 1979 · 503 citations

Inflammation, Medicinal Chemistry, Anti-inflammatory +7

Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets

Stephen R. Turner, John A. Tainer, William S. Lynn · Nature · 1975 · 390 citations

Biosynthesis, Engineering, Lipid Synthesis +6