Kinetic properties of dihydrofolate reductase from wild-type and mutant Plasmodium vivax expressed in Escherichia coli

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

Ulrich K. Laemmli · Nature · 1970 · 251.6K citations

Life Sciences, Microbiology, Molecular Biology +14

Chemistry and biology of pteridines

C. Fromageot · Biochimica et Biophysica Acta · 1956 · 1.2K citations

Pharmacy, Chemistry, Medicinal Chemistry +7

Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.

David S. Peterson, Wilbur K. Milhous, Thomas E. Wellems · Proceedings of the National Academy of Sciences · 1990 · 423 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Antifolate-resistant mutants of <i>Plasmodium falciparum</i> dihydrofolate reductase

Worachart Sirawaraporn, Tanajit Sathitkul, Rachada Sirawaraporn et al. · Proceedings of the National Academy of Sciences · 1997 · 342 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance.

Simon J. Foote, Denise Galatis, Alan F. Cowman · Proceedings of the National Academy of Sciences · 1990 · 307 citations

Life Sciences, Biochemistry, Pharmacology +17