Comparison of Global Brain Gene Expression Profiles Between Inbred Long‐Sleep and Inbred Short‐Sleep Mice by High‐Density Gene Array Hybridization

Abstract

This study identified 41 genes that are differentially expressed between brains of ILS and ISS mice. Some of them may have biological relevance in mediation of phenotypic variation between ILS and ISS mice for ethanol sensitivity. This study also demonstrates that parallel gene expression comparison with high-density cDNA arrays is a rapid and efficient way to discover potential genes and pathways involved in alcoholism and alcohol-related physiologic processes.