Concepedia

Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy

Thomas J. Povsic, William A. Wargin, John H. Alexander, J. Krasnow, Merrill Krolick, Mauricio G. Cohen, Roxana Mehran, Christopher E. Buller, Christoph Bode, Steven L. Zelenkofske,

European Heart Journal · 2011 · 43 citations · 18 references

DOI

Abstract

Pegnivacogin administered at a weight-adjusted dose of 1 mg/kg consistently achieves a high level of factor IX activity inhibition among patients with ACS and provides stable anticoagulation during cardiac catheterization. These findings support the dose of pegnivacogin selected for the RADAR study.

References

18

Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

Craig Tuerk, Larry Gold · Science · 1990 · 10.2K citations

, , +17

Relationship of Blood Transfusion and Clinical Outcomes in Patients With Acute Coronary Syndromes

Sunil V. Rao · JAMA · 2004 · 1K citations

Impact of Major Bleeding on 30-Day Mortality and Clinical Outcomes in Patients With Acute Coronary Syndromes

Steven V. Manoukian, Frederick Feit, Roxana Mehran et al. · Journal of the American College of Cardiology · 2007 · 798 citations

, , +11

Impact of Bleeding Severity on Clinical Outcomes Among Patients With Acute Coronary Syndromes

Sunil V. Rao, Kristi O’Grady, Karen S. Pieper et al. · The American Journal of Cardiology · 2005 · 631 citations

, , +13

RNA aptamers as reversible antagonists of coagulation factor IXa

Christopher P. Rusconi, Elizabeth Scardino, Juliana M. Layzer et al. · Nature · 2002 · 510 citations

, , +1