Concepedia

Enhancement of the affinity of 2′-O-Me-oligonucleotides for complementary RNA by incorporating a stereoregulated boranophosphate backbone

Yohei Nukaga, Tetsuhiko Takemura, Naoki Iwamoto, Natsuhisa Oka, Takeshi Wada

RSC Advances · 2014 · 10 citations · 24 references

DOI

Concepts

Abstract

<italic>P</italic>-stereodefined boranophosphate 2′-<italic>O</italic>-Me-oligoribonucleotides (2′-<italic>O</italic>-Me-PB-ORNs) were synthesized and we revealed that an all-(<italic>S</italic>p)-PB-backbone largely stabilized the duplex with RNA.

References

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