Developmental changes in the constitutive and inducible expression of cytochrome p450 3a2

Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes

David J. Waxman, Ghazi A. Dannan, F. Peter Guengerich · Biochemistry · 1985 · 599 citations

Medicine, Biochemistry, Endocrinology +11

Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.

Frank J. Gonzalez, Byeong Jun Song, James P. Hardwick · Molecular and Cellular Biology · 1986 · 297 citations · Full text

Life Sciences, Genetics, Molecular Biology +9

Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes.

Thomas A. Kocarek, Erin G. Schuetz, Steven Strom et al. · Drug Metabolism and Disposition · 1995 · 232 citations

Medicine, Pharmacology, Toxicology +11

Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family.

Frank J. Gonzalez, Daniel W. Nebert, James P. Hardwick et al. · Journal of Biological Chemistry · 1985 · 182 citations · Full text

Medicine, Molecular Biology, Molecular Genetics +10

Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression.

David J. Waxman, Gerald A. LeBlanc, Joseph J. Morrissey et al. · Journal of Biological Chemistry · 1988 · 137 citations · Full text

Medicine, Biochemistry, Endocrinology +17