Local anesthetics reduce the inhibitory neurotransmitter-induced current in dissociated hippocampal neurons of the rat

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Owen P. Hamill, Alain Marty, Erwin Neher et al. · Pflügers Archiv - European Journal of Physiology · 1981 · 18.5K citations

Natural Sciences, Biophysics, Cell Biology +16

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

Bertil Hille · The Journal of General Physiology · 1977 · 1.8K citations · Full text

Medicine, Pharmacology, Anesthesia +16

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

Erwin Neher, Joe Henry Steinbach · The Journal of Physiology · 1978 · 849 citations · Full text

Medicine, Pharmacology, Physiology +16

Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons

Kazuyuki Murase, Pan Dong Ryu, Mirjana Randić · Neuroscience Letters · 1989 · 434 citations

Life Sciences, Neurobiology, Neuroscience +14

Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA.

Kenneth R. Courtney · Journal of Pharmacology and Experimental Therapeutics · 1975 · 394 citations

Medicine, Neurobiology, Pharmacology +17