Concepedia

Syntheses of novel high affinity ligands for opioid receptors

Mark P. Wentland, Rongliang Lou, Qun Lu, Yigong Bu, C. Denhardt, Jin Jin, Rakesh Ganorkar, Melissa A. VanAlstine, Chengyun Guo, Dana J. Cohen,

Bioorganic & Medicinal Chemistry Letters · 2009 · 99 citations · 13 references

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13

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

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Application of the message-address concept in the design of highly potent and selective non-peptide .delta. opioid receptor antagonists

P. S. Portoghese, Marjia Sultana, Hiroshi Nagase et al. · Journal of Medicinal Chemistry · 1988 · 305 citations

, , +15

Design and Synthesis of Novel Dimeric Morphinan Ligands for κ and μ Opioid Receptors

John L. Neumeyer, Ao Zhang, Wennan Xiong et al. · Journal of Medicinal Chemistry · 2003 · 79 citations · Full text

, , +17

Microwave-Promoted Pd-Catalyzed Cyanation of Aryl Triflates:  A Fast and Versatile Access to 3-Cyano-3-desoxy-10-ketomorphinans

Ao Zhang, John L. Neumeyer · Organic Letters · 2002 · 70 citations

, , +16

Palladium-catalyzed cyanation of hindered, electron-rich aryl triflates by zinc cyanide

Hitoshi Kubota, Kenner C. Rice · Tetrahedron Letters · 1998 · 60 citations

, , +11