JAMA · 1974 · 70 citations · 0 references
PharmacyPharmacokineticsPharmacologyDialysisRenal PharmacokineticsRenal PharmacotherapyNephrotoxicity ManagementPharmacokinetics In Renal ImpairmentRenal Dose AdjustmentRenal Dose ModificationRenal Drug ClearanceRenal PharmacologyChronic Renal InsufficiencyDialysis AdjustmentMaintenance IntervalsMedication-related NephrotoxicityRenal Adverse EffectsRenal Dosing AlgorithmsRenal Function-based DosingSerum Half-life
Five tables suggest maintenance dosage intervals for common drugs used in patients with renal insufficiency, based on data in the literature. If information about a particular drug is unavailable, emphasis is given to biological half-life, normal pharmacology, and creatinine clearance for modification of the usual dose schedules. Nephrotoxicity or adverse effects in patients with renal disease are noted and adjustments for concurrent dialysis suggested. (<i>JAMA</i>230:1544-1553, 1974)