Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

Nelson L. Brock, Alexander Nikolay, Jeroen S. Dickschat

Chemical Communications · 2014 · 81 citations · 17 references

Concepts

Abstract

The biosynthesis of tropodithietic acid was investigated using a combinatorial approach of feeding experiments, gene knockouts and bioinformatic analyses. The mechanism of sulfur introduction is distinct from known mechanisms in holomycin, thiomarinol A and gliotoxin biosynthesis.

References

17