A novel mutation in PTPRC interferes with splicing and alters the structure of the human CD45 molecule

Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS)

Charles R. Newton, Alexander Graham, Lesley Heptinstall et al. · Nucleic Acids Research · 1989 · 2.5K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

Junko Irie-Sasaki, Takehiko Sasaki, Wataru Matsumoto et al. · Nature · 2001 · 564 citations

Life Sciences, Cell Biology, Immunology +14

Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

Kenji Kishihara, Josef Penninger, Valerie A. Wallace et al. · Cell · 1993 · 492 citations

Life Sciences, Immunology, Molecular Biology +13

Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease

Chun Kung, Jeanette T. Pingel, Markku Heikinheimo et al. · Nature Medicine · 2000 · 310 citations

Life Sciences, Genetics, Immunology +13

Dimerization-Induced Inhibition of Receptor Protein Tyrosine Phosphatase Function Through an Inhibitory Wedge

Ravindra Majeti, A.M. Bilwes, Joseph P. Noel et al. · Science · 1998 · 262 citations

Life Sciences, Biochemistry, Molecular Biology +17