Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes

Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States

George Ostapowicz, Robert J. Fontana, Frank Vinholt Schiødt et al. · Annals of Internal Medicine · 2002 · 2.2K citations

Medicine, Internal Medicine, Acute Care Medicine +14

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

Allan E. Rettie, Kenneth R. Korzekwa, Kent L. Kunze et al. · Chemical Research in Toxicology · 1992 · 602 citations

Medicine, Pharmacology, Toxicology +17

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

Raimund M. Peter, Ronald Boecker, Philippe Beaune et al. · Chemical Research in Toxicology · 1990 · 535 citations

Medicine, Pharmacology, Toxicology +11

Preparation and Properties of Partially Purified Cytochrome P-450 and Reduced Nicotinamide Adenine Dinucleotide Phosphate-Cytochrome P-450 Reductase from Rabbit Liver Microsomes

Theodore A. van der Hoeven, Minor J. Coon · Journal of Biological Chemistry · 1974 · 519 citations · Full text

Medicine, Biochemistry, Pharmacology +16

Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics

Chris J. Patten, Paul E. Thomas, Robert L. Guy et al. · Chemical Research in Toxicology · 1993 · 413 citations

Medicine, Pharmacology, Toxicology +17