(25 <i>S</i>)‐1α, 25, 26‐Trihydroxycholecalciferol, a New Vitamin D₃ Metabolite: Synthesis and Absolute Stereochemistry at C(25)

Abstract

Abstract The 1α, 25, 26‐trihydroxy metabolite of vitamin D 3 , isolated from bovine serum, was shown to possess the (25 S )‐configuration by HPLC. comparison of the 1, 3, 26‐triacetate derivative with authentic (25 R )‐ and (25 S )‐samples. The convergent synthesis of (25 R )‐1α, 25, 26‐ and (25 S )‐1α, 25, 26‐trihydroxycholecalciferols ( 10a ) and ( 10b ) has been accomplished.