American Journal of Clinical Oncology · 2000 · 70 citations · 9 references
MedicineOncologyPharmacologyCancer PharmacologyChemotherapyMedical OncologyHepatocellular Carcinoma PharmacotherapyOncology PharmacologyOral Anticancer AgentsPharmacodynamics Of Anticancer AgentsPharmacodynamics Of Anticancer DrugsDurable Clinical ResponseHepatocellular Carcinoma TreatmentLiver Tumor TherapySedative AdministrationThalidomide Analogs
Thalidomide, a sedative agent previously associated with severe fetal malformations, has anti-angiogenic activity. We describe the antitumor effects of thalidomide in a patient with hepatocellular carcinoma that was refractory to systemic and intraarterial therapy.
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Thalidomide is an inhibitor of angiogenesis.
Robert J. D’Amato, Michael Loughnan, Evelyn Flynn et al. · Proceedings of the National Academy of Sciences · 1994 · 2.5K citations
Induction of angiogenesis during the transition from hyperplasia to neoplasia
J Folkman, Karol Watson, Donald E. Ingber et al. · Nature · 1989 · 1.9K citations
Medicine, Cell Biology, Oncology +10
ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS
Judah Folkman, Ezio Merler, Charles M. Abernathy et al. · The Journal of Experimental Medicine · 1971 · 1.7K citations · Full text
Medicine, Cancer Biology, Oncology +15