Concepedia

Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives

Heuisul Park, Kyeongsik Min, Hyo-Shin Kwak, Ki Dong Koo, Dongchul Lim, Sang-Won Seo, Jae-Ung Choi, Bettina Platt, Deog-Young Choi

Bioorganic & Medicinal Chemistry Letters · 2008 · 23 citations · 8 references

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

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Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor

Hong Lin, Gerald Koelsch, Xinli Lin et al. · Science · 2000 · 706 citations

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

Steven L. Roberds · Human Molecular Genetics · 2001 · 703 citations

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Identification of a Small Molecule Nonpeptide Active Site β-Secretase Inhibitor That Displays a Nontraditional Binding Mode for Aspartyl Proteases

Craig A. Coburn, Shawn J. Stachel, Yue‐Ming Li et al. · Journal of Medicinal Chemistry · 2004 · 117 citations · Full text

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Design and Synthesis of Statine-Based Cell-Permeable Peptidomimetic Inhibitors of Human β-Secretase

Roy K. Hom, Larry Y. Fang, Shumeye Mamo et al. · Journal of Medicinal Chemistry · 2003 · 78 citations · Full text

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