Pretreatment with recombined human erythropoietin attenuates ischemia–reperfusion-induced lung injury in rats

Abstract

Pretreatment with rhEPO appears to attenuate I/R-induced lung injury. This function is partly related with the capacity that rhEPO inhibits the accumulation of polymorphonuclear neutrophils in lung tissue and decreases the systematic expression of tumor necrosis factor-alpha.