Determination of thiazole-4-carboxamide adenine dinucleotide (TAD) levels in mononuclear cells of leukemic patients treated with tiazofurin

2-.beta.-D-ribofuranosylthiazole-4-carboxamide, a novel potential antitumor agent for lung tumors and metastases

R. K. ROBINS, Prem C. Srivastava, V. L. Narayanan et al. · Journal of Medicinal Chemistry · 1982 · 147 citations

Medicine, Oncology, Pharmacology +5

Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-β-d-ribofuranosylthiazole-4-carboxamide NSC 286193)

Hiremagalur N. Jayaram, Robert L. Dion, Robert I. Glazer et al. · Biochemical Pharmacology · 1982 · 144 citations

Medicine, Medicinal Chemistry, Oncology +9

Biochemically directed therapy of leukemia with tiazofurin, a selective blocker of inosine 5'-phosphate dehydrogenase activity.

Guido Tricot, Hiremagalur N. Jayaram, Elizabeth Lapis et al. · PubMed · 1989 · 127 citations

Medicine, Pharmacology, Pharmacotherapy +16

The conversion of 2-β-D-ribofuranosylthiazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties

David A. Cooney, Hiremagalur N. Jayaram, Gulilat Gebeyehu et al. · Biochemical Pharmacology · 1982 · 122 citations

Life Sciences, Biochemistry, Medicinal Chemistry +11

Modulation of IMP dehydrogenase activity and guanylate metabolism by tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide).

May S. Lui, Mary A. Faderan, J. J. Liepnieks et al. · Journal of Biological Chemistry · 1984 · 114 citations · Full text

Medicine, Oncology, Pharmacology +13