STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression

Abstract

The DNA damage response (DDR) upregulates the expression of NKG2D ligands (NKG2DLs).^1,2 We have recently reported that the DDR also induces the presence of cytosolic DNA in B-cell lymphoma cells, which leads to the activation of STING-dependent cytosolic DNA sensor pathways and the expression of RAE-1 ligands for NKG2D.^3.