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3-Amino-5-hydroxybenzoic acid as a key intermediate in ansamycin and maytansinoid biosynthesis
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1980
Year
Medicinal ChemistryBiosynthesisBioorganic ChemistryMaytansinoid BiosynthesisBiochemistryKey IntermediateStreptomycete CultureSpecific IncorporationNatural SciencesBiotransformationSecondary MetaboliteNatural Product Biosynthesis3-Amino-5-hydroxybenzoic AcidChemical BiologyPharmacologyProtein BiosynthesisNatural Product Synthesis
The specific incorporation of 3-amino-5-hydroxybenzoic acid (2) into actamycin (1) by a Streptomycete culture establishes this amino-acid as a key intermediate in ansamycin and maytansinoid biosynthesis.