New England Journal of Medicine · 1961 · 105 citations · 102 references
Natural SciencesBiochemistryChemistryInorganic ChemistryMetabolismMineral MetabolismCopper MetabolismCopper ToxicityCopper ToxicologyHeavy Metal ContaminationHeavy Metal MetabolismMetal ToxicityCopper ContentCopper Metabolism Disorders
THE element copper is ubiquitously distributed on the earth's surface. Its tin alloy, bronze, has been in use for four thousand years, and the salts of the metal were employed in the therapy of eye disease in Babylon, Assyria and Egypt.1 Copper was identified in plant2 , 3 and animal4 material a hundred and forty years ago and was considered a contaminant. It is only in this century that it has been recognized as an essential constituent of all living things and that derangements in copper metabolism have been recognized in human and animal diseases.Distribution of Copper in the BodyCopper . . .
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Trace Elements in Human and Animal Nutrition
E. J. UNDERWOOD · Soil Science · 1963 · 4.5K citations · Full text
Metalloenzymes and Myocardial Infarction
New England Journal of Medicine · 1956 · 658 citations
Carl Holmberg, C.‐B. Laurell, Poul Gjertsen · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · 1948 · 472 citations · Full text