Chiral Scandium‐Catalyzed Enantioselective Hydroxymethylation of Ketones in Water

Abstract

Form with formalin: Scandium-catalyzed enantioselective hydroxymethylation of ketones has been developed using aqueous formaldehyde (formalin) in water. The addition of a catalytic amount of pyridine enables the use of ketones directly in asymmetric hydroxymethylation reactions.