Publication | Closed Access
Asymmetric Direct Aldol Reaction Assisted by Water and a Proline‐Derived Tetrazole Catalyst
567
Citations
48
References
2004
Year
EngineeringOrganic ChemistryChemistryChemical EngineeringHomogeneous CatalysisStereoselective SynthesisBiochemistryAsymmetric SynthesisCatalysisAsymmetric CatalysisEnantioselective SynthesisCatalytic SynthesisBiomolecular EngineeringDirect Aldol ReactionsNatural SciencesMolecular CatalysisHigh Water-affinitySynthetic ChemistryProline‐derived Tetrazole Catalyst
Just add water to improve the performance of direct aldol reactions like that shown. Previously, aldehydes with high water-affinity or -solubility were considered unsuitable for asymmetric synthesis.
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