Concepedia
Bioorganic & Medicinal Chemistry Letters · 2006 · 15 citations · 30 references
Open access
PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryStructure-activity RelationshipsEnzyme InhibitionLigand BindingNatural Product Drug DiscoveryStructure-activity Relationship AnalysisChemical Synthesis Of AnaloguesTransition-state Analogue Inhibitors
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Use of the electrostatic potential at the molecular surface to interpret and predict nucleophilic processes
Per J. R. Sjöberg, Peter Politzer · The Journal of Physical Chemistry · 1990 · 455 citations
Natural Sciences, Chemistry, Biomolecular Modeling +13
Crystal Structure of Human MMP9 in Complex with a Reverse Hydroxamate Inhibitor
Siân Rowsell, Paul Hawtin, Claire A. Minshull et al. · Journal of Molecular Biology · 2002 · 257 citations
Life Sciences, Medicinal Chemistry, Pharmacology +9
Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor
John M. Clements, R. Paul Beckett, Anthony Brown et al. · Antimicrobial Agents and Chemotherapy · 2001 · 233 citations · Full text
Life Sciences, Biochemistry, Pharmacology +17
Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis
Michael Holmes, B.W. Matthews · Biochemistry · 1981 · 233 citations
Natural Sciences, Biochemistry, Chemistry +14
Electrostatic stabilization can explain the unexpected acidity of carbon acids in enzyme-catalyzed reactions
J. Peter Guthrie, Ronald Kluger · Journal of the American Chemical Society · 1993 · 156 citations
Life Sciences, Biochemistry, Chemistry +16