High levels of synaptosomal Na+–Ca2+ exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease

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Neurodegenerative Diseases, Cognitive Science, Brain Function +12

Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

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Debora A. Nicoll, Stefano Longoni, Kenneth D. Philipson · Science · 1990 · 743 citations

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

Kishore V. Kuchibhotla, Samuel T. Goldman, Carli Lattarulo et al. · Neuron · 2008 · 610 citations · Full text

Neurodegenerative Diseases, Molecular Physiology, Molecular Neuroscience +13

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

Rebecca J. Griffin, Aileen M. Moloney, Mary Kelliher et al. · Journal of Neurochemistry · 2005 · 453 citations

Cell Death, Neurochemical Biomarkers, Social Sciences +20