DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia

XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage

Murielle Masson, Claude Niedergang, Valérie Schreiber et al. · Molecular and Cellular Biology · 1998 · 904 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Metabolic gene polymorphism frequencies in control populations.

Seymour Garte, Laura Gaspari, Anna-Karin Alexandrie et al. · PubMed · 2001 · 847 citations

Medicine, Genetics, Molecular Genetics +13

Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans.

Mei-Ling Shen, I M Jones, H.W. Mohrenweiser · PubMed · 1998 · 774 citations

Life Sciences, Genetics, Molecular Genetics +17

XRCC1 Polypeptide Interacts with DNA Polymerase   and Possibly Poly (ADP-Ribose) Polymerase, and DNA Ligase III Is a Novel Molecular 'Nick-Sensor' In Vitro

Keith W. Caldecott, Saïd Aoufouchi, Peter Johnson et al. · Nucleic Acids Research · 1996 · 612 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

XRCC1 Stimulates Human Polynucleotide Kinase Activity at Damaged DNA Termini and Accelerates DNA Single-Strand Break Repair

Claire J Whitehouse, Richard Taylor, Angela Thistlethwaite et al. · Cell · 2001 · 604 citations · Full text

Life Sciences, Genetics, Molecular Biology +9