A new water‐soluble <i>N</i>‐protecting group, 2‐[phenyl(methyl)sulfonio]ethyloxycarbonyl tetrafluoroborate, and its application to solid phase peptide synthesis in water

Abstract

Abstract A new water‐soluble N ‐protecting group, 2‐[phenyl(methyl)sulfonio]ethyloxycarbonyl tetrafluoroborate, has been prepared and its application to solid phase peptide synthesis in water has been studied. Leu‐enkephalin amide was successfully synthesized in water by the solid phase method using this protecting group. Copyright © 2001 European Peptide Society and John Wiley &amp; Sons, Ltd.