Concepedia

In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA Receptor α5 Subtype-Selective Inverse Agonist

John Atack, Karen Maubach, Keith A. Wafford, Desmond O’Connor, A. David Rodrigues, David C. Evans, F.D. Tattersall, Mark S. Chambers, Angus M. MacLeod, Wai-si Eng,

Journal of Pharmacology and Experimental Therapeutics · 2009 · 71 citations · 25 references

DOI

Concepts

References

25

GABA<sub>A</sub>‐receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits

Jean‐Marc Fritschy, Hanns Möhler · The Journal of Comparative Neurology · 1995 · 1.2K citations

, , +17

Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes

Uwe Rudolph, Florence Crestani, Dietmar Benke et al. · Nature · 1999 · 1.2K citations

, , +14

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype

Ruth M. McKernan, T.W. Rosahl, David S. Reynolds et al. · Nature Neuroscience · 2000 · 941 citations

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Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

K. Sandy Pang, Malcolm Rowland · Journal of Pharmacokinetics and Biopharmaceutics · 1977 · 798 citations

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Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABA<sub>A</sub>Receptor

Neil Collinson, Frederick M. Kuenzi, Wolfgang Jarolimek et al. · Journal of Neuroscience · 2002 · 629 citations · Full text

, , +17