One‐pot synthesis of polymeric nanoparticle by ring‐opening metathesis polymerization

Abstract

Abstract Shell‐functionalized polymeric nanoparticle was prepared through the method of polymerization‐induced self‐assembly of block copolymers [poly(2,3‐bis(2‐bromoisobutyryloxymethyl)‐5‐norbornene)‐ block ‐poly(7‐oxanorborn‐5‐ene‐exo‐exo‐2,3‐dicarboxylic acid dimethyl ester), PBNBE‐ b ‐PONBDM] via one‐pot ring‐opening metathesis polymerization of 2,3‐bis(2‐bromoisobutyryloxymethyl)‐5‐norbornene (BNBE) and 7‐oxanorborn‐5‐ene‐exo‐exo‐2,3‐dicarboxylic acid dimethyl ester (ONBDM) in a selective solvent. The compositions and the molecular weights of the copolymers were estimated by 1 H‐NMR and gel permeation chromatography. The micelles were characterized by dynamic light scattering, transmission electron micrograph, and atomic force microscopy. The results indicated that the spherical micelles constructed with bromine‐bearing PBNBE shell and PONBDM core were stable and reproducible in toluene. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010