Concepedia

On the Application of t-Butyldimethylsilyl Group in Chemical RNA Synthesis. Part I.<sup>31</sup>P NMR Study of 2′-O-t-BDMSi Group Migration During Nucleoside 3′-OH Phosphorylation and Phosphitylation Reactions

Jan Milecki, Piotr Dembek, Wiesław Z. Antkowiak, Zofia Gdaniec, Slawomir S. Mielewczyk, Ryszard W. Adamiak

Nucleosides and Nucleotides · 1989 · 21 citations · 29 references

DOI

Concepts

Abstract

Abstract 31P NMR spectroscopy has been used for evaluation of 2′-O-t-BDMSi group migration during reactions of suitably protected 3′-OH ribonucleosides with P(V) and P(III) reagents used in major methodologies for oligoribonucleotide synthesis.

References

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The automated chemical synthesis of long oligoribuncleotides using 2'-O-silylated ribonucleoside 3'-O-phosphoramidites on a controlled-pore glass support: synthesis of a 43-nucleotide sequence similar to the 3'-half molecule of an Escherichia coli formylmethionine tRNA

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The chemical synthesis of oligo- and poly-nucleotides by the phosphotriester approach

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<i>In situ</i>activation of bis-dialkylaminophosphines—a new method for synthesizing deoxyoligonucleotides on polymer supports

Anthony D. Barone, Jin Tang, Marvin H. Caruthers · Nucleic Acids Research · 1984 · 243 citations · Full text

The synthesis of oligoribonucleotides. II. The use of silyl protecting groups in nucleoside and nucleotide chemistry. VII

Kelvin K. Ogilvie, Serge L. Beaucage, Aria L. Schifman et al. · Canadian Journal of Chemistry · 1978 · 238 citations · Full text

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