A priori delineation of a peptide which mimics a discontinuous antigenic determinant

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

H. Mario Geysen, Rob H. Meloen, S J Barteling · Proceedings of the National Academy of Sciences · 1984 · 1.5K citations · Full text

Life Sciences, Biochemistry, Immunology +17

Tapping the immunological repertoire to produce antibodies of predetermined specificity

Richard A. Lerner · Nature · 1982 · 462 citations

Pharmacy, Immunology, Adaptive Immunity +13

Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.

Henry Niman, Richard A. Houghten, L E Walker et al. · Proceedings of the National Academy of Sciences · 1983 · 378 citations · Full text

Life Sciences, Biochemistry, Immunology +14

Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein.

H. Mario Geysen, S J Barteling, Rob H. Meloen · Proceedings of the National Academy of Sciences · 1985 · 289 citations · Full text

Life Sciences, Immunology, Infectious Diseases +17

Antibodies That React with Predetermined Sites on Proteins

J. Gregor Sutcliffe, Thomas M. Shinnick, Nicola Green et al. · Science · 1983 · 219 citations

Life Sciences, Biotechnology, Immunology +15