Nepalensinols D-G, New Resveratrol Oligomers from Kobresia nepalensis (Cyperaceae) as Potent Inhibitors of DNA Topoisomerase II

Abstract

Four new resveratrol oligomers, nepalensinols D-G, were isolated from the stem of Kobresia nepalensis (Cyperaceae). The structures were determined by detailed NMR spectral analysis. The compounds were assessed for their inhibitory activity against human topoisomerase II, a potential target of anti-tumor agents. These stilbenoids showed potent inhibitory activity against human topoisomerase II with IC50 values of 5-15 microM.