Lipopolysaccharides Shapes the Human Wharton's Jelly-Derived Mesenchymal Stem Cells<b><i>in Vitro</i></b>

Abstract

These data suggest that LPS engagement shapes hWJ-MSCs and results in the production of pro-inflammatory cytokines and inhibitory immune mediators, showing TLR4 agonist induces the hWJ-MSCs polarization to a pro-inflammatory and immunosuppressive state, which may be beneficial for the exploration of the clinical potential of hWJ-MSCs.