Beneficial Effect of Tolerogenic Dendritic Cells Pulsed with <scp>MOG</scp> Autoantigen in Experimental Autoimmune Encephalomyelitis

Abstract

We found that VitD3-TolDC-MOG treatment showed a beneficial effect, not only decreasing the incidence of the disease but also reducing the severity of the clinical signs mediated by induction of regulatory T cells (Treg), as well as IL-10 production and reduction of Ag-specific lymphoproliferation. Our results support VitD3-TolDC-peptide(s) treatment as a potential strategy to restore tolerance in autoimmune diseases such as MS.