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New Structural Motifs for Hammerhead Ribozymes. Catalytic Activity of Abasic Nucleotide Substituted Ribozymes
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1995
Year
Hammerhead RibozymesBioorganic ChemistryMolecular BiologyOrganic ChemistryHammerhead RibozymeNucleic Acid ChemistryProtein X-ray CrystallographyCatalytic ActivityStereoselective SynthesisBiochemistryNew Structural MotifsOligonucleotide2-Cyanoethyl NNatural Product SynthesisEnantioselective SynthesisStructural BiologyNatural SciencesEnzyme CatalysisSynthetic Chemistry
Abstract The synthesis of 1-deoxy-D-ribofuranose-3-(2-cyanoethyl N,N-diisopropylphosphoramidite) (6) from D-ribose and its incorporation into a hammerhead ribozyme is described.