Concepedia

Hammerhead Ribozymes

Hammerhead Ribozymes is a small, self-cleaving ribozyme that belongs to the class of catalytic RNA molecules and is distinguished by its conserved secondary structure comprising three base-paired stems radiating from a central core of conserved nucleotides, enabling site-specific phosphodiester bond cleavage in RNA substrates.

792

Publications

45.5K

Citations

2K

Authors

579

Institutions

Publications per year

2017–2026

45

Parents

Publications

792

Three-dimensional structure of a hammerhead ribozyme

Heinz W. Pley, Kevin Flaherty, David McKay · Nature · 1994 · 957 citations

, , +14

Ribozymes as Potential Anti-HIV-1 Therapeutic Agents

Nava Sarver, Edouard M. Cantin, Pairoj S. Chang et al. · Science · 1990 · 663 citations

, , +15

Sequence requirements of the hammerhead RNA self-cleavage reaction

Duane E. Ruffner, Gary D. Stormo, Olke C. Uhlenbeck · Biochemistry · 1990 · 471 citations

, , +11

Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes

Wolfgang A. Pieken, David B. Olsen, Fritz Benseler et al. · Science · 1991 · 469 citations

, , +17

In vitro selection and characterization of a highly efficient Zn(II)-dependent RNA-cleaving deoxyribozyme

J. Li · Nucleic Acids Research · 2000 · 457 citations · Full text

, , +16

1–5 of 792

Authors

2K

  1. OC
    Olke C. Uhlenbeck

    University of Colorado Boulder, United States

    33 publications · 3K citations

    24

    h-index

  2. KT
    Kazunari Taira

    National Institute of Advanced Industrial Science and Technology, Japan

    35 publications · 1.5K citations

    22

    h-index

  3. RF
    Ricardo Flores

    Instituto de Biología Molecular y Celular de Plantas, Spain

    24 publications · 1.8K citations

    21

    h-index

  4. WG
    W. G. Scott

    European Organization for Nuclear Research, Switzerland

    18 publications · 2.1K citations

    18

    h-index

  5. JJ
    John J. Rossi

    City of Hope, United States

    21 publications · 1.7K citations

    16

    h-index

1–5 of 2K

Institutions

579

  1. University of Colorado Boulder

    Boulder, United States

    34 h-index

    146 publications

    15.3K citations

  2. Instituto de Biología Molecular y Celular de Plantas

    Valencia, Spain

    29 h-index

    104 publications

    7.8K citations

  3. Universitat Politècnica de València

    Valencia, Spain

    21 h-index

    59 publications

    4K citations

  4. National Institute of Advanced Industrial Science and Technology

    Tsukuba, Japan

    20 h-index

    124 publications

    4.3K citations

  5. Max Planck Institute of Experimental Medicine

    Göttingen, Germany

    19 h-index

    49 publications

    5K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    17 h-index

    68 publications

    3.7K citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    16 h-index

    38 publications

    4.5K citations

  8. City of Hope

    Lancaster, United States

    16 h-index

    66 publications

    5.7K citations

1–8 of 579

Venues

  1. Nucleic Acids Research

    104 publications · 6.1K citations

    45

    h-index

  2. Biochemistry

    62 publications · 4.8K citations

    39

    h-index

  3. Journal of the American Chemical Society

    JACS · 50 publications · 2.7K citations

    34

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 38 publications · 3.5K citations

    32

    h-index

  5. PubMed

    Repository · 51 publications · 3.2K citations

    30

    h-index

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