Concepedia

Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells.

Warner C. Greene, R J Robb, Penny B. Svetlik, C M Rusk, J M Depper, Warren J. Leonard

The Journal of Experimental Medicine · 1985 · 119 citations · 16 references

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Abstract

Human interleukin 2 (IL-2) receptor cDNA derived from HUT 102B2 cells was stably expressed in murine L cells. These L cell transfectants (a) displayed surface receptors of the aberrant size of the IL-2 receptors on HUT 102B2 cells, (b) did not respond to exogenous IL-2 with augmented proliferation, and (c) expressed low affinity but not high affinity receptors for IL-2.

References

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A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.

Takashi Uchiyama, S Broder, Thomas A. Waldmann · The Journal of Immunology · 1981 · 1.3K citations · Full text

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T cell growth factor receptors. Quantitation, specificity, and biological relevance

RJ Robb, Allan Munck, KA Smith · The Journal of Experimental Medicine · 1981 · 1.1K citations · Full text

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A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor

Warren J. Leonard, Joel M. Depper, Takashi Uchiyama et al. · Nature · 1982 · 864 citations

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Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

Warren J. Leonard, Joel M. Depper, Gerald R. Crabtree et al. · Nature · 1984 · 857 citations

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