Anti-Tissue Transglutaminase Antibodies From Celiac Patients Are Responsible for Trophoblast Damage via Apoptosis In Vitro

Abstract

We showed that the binding of anti-tTG antibodies to trophoblast might represent a key mechanism by which the embryo implantation and pregnancy outcome are impaired in untreated celiac pregnant women. Because healthy trophoblast development is essential for placental and fetal development, these data provide a novel mechanism for CD-induced infertility, early pregnancy loss, and intrauterine growth retardation.